Abstract Background Metastases are the major cause of cancer-related morbidity and mortality.By the time cancer cells detach from their primary site to eventually spread to distant sites, they need to acquire the ability to survive in non-adherent conditions and to proliferate within a new microenvironment in spite of stressing conditions that may
Proteomic test for anti-PD-1 checkpoint blockade treatment of metastatic melanoma with and without BRAF mutations
Abstract The therapeutic landscape in metastatic melanoma has changed dramatically in the last decade, with the success of immune checkpoint inhibitors resulting in durable responses for a large number of patients.For patients with BRAF mutations, combinations of BRAF and MEK inhibitors demonstrated response rates and benefit comparable to those fr
Body Size Mediated Coexistence in Swans
Differences in body sizes may create a trade-off between foraging efficiency (foraging gains/costs) and access to resources.Such a trade-off provides a potential mechanism for ecologically similar species to coexist on one resource.We explored this hypothesis for tundra (Cygnus columbianus) and trumpeter swans (Cygnus buccinator), a federally Bed R
Atomic Stress State Inside fcc and bcc Random Alloys: A First-Principles Approach
The stress state at an atomic level and its governing physics inside a random Circle Plaque LED Night Light alloy are essential elements in developing a model for solid solution strengthening in random alloys, which is one of the primary strengthening mechanisms of high-entropy alloys (HEAs).Through first-principles calculation, we investigated the